Use Of Medical Devices To Detect Tumour Cells In The Blood – Pubrica

Medical devices are effective tools to screen, diagnosis, provide treatment or to manage the disease or illness when it can't be cured(WHO, 2020).Initially, in 2008, the World Health Organization (WHO) has initiated a survey globally and estimated that 1.5 million medical devices exist,in more than 10,000 types of generic device groups(World Health Organization, 2018). The significant demand for the use of appropriate medical devices is to diagnose mainly the tumours to manage the clinical interventions(Organization, 2017).

Thin transparency exists between the terminology of tumours and cancers, which if used interchangeably might mislead and becomes a reason for confusing treatment. However, clinicians systematic review better understand the difference between tumours and cancers, where tumours are considered as a mass of cells and cancers are the life-threatening tumours(hopkins John, 2018). Hence it becomes essential to use efficient medical devices to capture the circulating tumour cells in the bloodstream to provide potential evidence for early detection of cancer(Sukel, 2019).

Clinical Researchers have designed a device called cytophone which detects cancer-causing cells inside the patient's body.This device shots the laser pulses on the blood vessels of a person's hand that is fixed in a customized holder.When the laser beams catch the passing through melanoma cells, it heats the pigment inside and produces sound waves that are detectable by an ultrasound transducer.

A novel device which is ultrasensitive was invented by Kansas researchers to detect mainly ovarian cancer even in the minimum amount of plasma or in patient's blood droplet is the lab-on-a-chip, which is the key innovation made through "3D nanopatternedmicrofluid chip"(Cohut, 2019). In this scientific research technique, it combines and senses with the biological elements depending on the herringbone pattern that is recognized by nature, and pushes the exosomes in contact with the chip's which is more efficiently sensing surface and this process is known as"mass transfer”.

Another device developed by Michigan engineers and doctors was a wearable device,which could accurately diagnose and treat cancer more effectively. This device was experimented on animals initially, and observed circulating tumour cells in the blood and was captured to eliminate tumour cells permanently.  Further, scientific analysis in the process of development, the gadget that filters the blood was used to diagnose and later used to treat metastatic cancer in humans.

It was examined initial on dogs, the graphene oxide nanosheets were embedded to filter the collected. These graphene oxide nanosheets coated with antibodies that adhere to the cancer cells. It generally captures 3.5 times more tumour cells per millilitre of blood than usual blood drawn from an individual. On the other hand, Heparin supply was provided to avoid clotting of blood while it is still in the device. Finally, the blood devoid of the cancer cells that stuck to the nanosheets were pumped back into the body.

In conclusion, these devices bring out early and effective detection of disease with the noninvasive process. Its potential evaluation might provide accurate information to doctors to treat their patients at the initial stage. As the diagnosis through medical devices is comparatively cheaper, easier and reliable to producean accurate diagnosis, further scientists would expand the applications of the medical devices in detecting other various diseases.

Reference: https://pubrica.com/services/research-services/

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