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Why You Should Spend More Time Thinking About Physician Writing

  In brief   Being a physician has always been a demanding occupation. This is especially true for primary care physicians, who strive to provide and coordinate complete treatment for their patients. Such a goal necessitates availability, a broad range of medical expertise, effective utilization of the local healthcare system, and attention to the "big picture" and the details of a patient's life and health.   Introduction   When physicians learn to write creatively, they perceive significant and even career-saving benefits. Their comments on their experiences and what is significant in their lives and jobs help them become better physicians.   Why physicians make good creative writers   If we consider our life experiences to be a well from which to draw while becoming writers, physicians have an unusually deep well. They're engrossed in stories. They see bravery, cures, and spectacular failures. They see incredible situations, hear tragic words, make life-...
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Recent technologies and future perspectives in cancer therapies – Pubrica

 

Cancer is one of the leading causes of mortality globally, and many research studies have focused in the last decade on developing novel therapeutics to lessen the negative effects of existing treatments. Tumors become extremely heterogeneous as cancer progresses, resulting in a mixed population of cells with varying molecular characteristics and therapeutic responses.This variability may be seen at both a geographic and temporal level, and it is a significant element in the establishment of resistance phenotypes, which is aided by a selection pressure applied during drug administration.

Natural antioxidants in cancer therapy:

Exogenous assaults to the human body, such as ultraviolet (UV) rays, air pollution, and tobacco smoke, cause the creation of reactive species, particularly oxidants and free radicals, which are responsible for the start of many diseases, including cancer. These molecules can be formed as a result of drug delivery in the clinic, but they can also be formed spontaneously inside our cells and tissues by mitochondria and peroxisomes, as well as macrophage metabolism, during normal physiological aerobic activities.



Targeted therapy and immunotherapy:

The low specificity of chemotherapeutic medicines for cancer cells is one of the key difficulties with conventional cancer treatments. In fact, most medications have severe side effects because they act on both healthy and sick organs. Clinical Researchers are working hard to figure out how to target only the targeted site. Because of their enhanced permeability and retention effect (EPR), nanoparticles have sparked a lot of attention because of their tendency to aggregate more in tumor tissues. The small size of nanoparticles, as well as the leaky vasculature and poor lymphatic drainage of neoplastic tissues, are used in this passive targeting method.

Approximately 2,900 gene therapy clinical trials are now underway, with cancer accounting for 66.6 percent of them. Different strategies are under evaluation for cancer gene therapy: 1) targeted silencing of oncogenes, 2) expression of pro-apoptotic and chemo-sensitising genes 3) expression of genes able to solicit specific antitumour immune responses and 4) expression of wild type tumour suppressor genes.

Thermal ablation and magnetic hyperthermia:

The term "thermal ablation of tumors" refers to a set of procedures that use heat (hyperthermia) or cold (hypothermia) to eliminate cancerous tissues[10]. Cell necrosis is reported to occur at temperatures as low as -40°C and as high as 60°C.. Cell necrosis is reported to occur at temperatures as low as -40°C and as high as 60°C.

Radiomics and pathomics:

Many clinical research projects are focusing on the development of novel image processing techniques in order to extrapolate information through quantification and disease classification. To detect disease phenotypes, flexible databases are necessary to accommodate large amounts of data from gene expression, histology, 3D tissue reconstruction (MRI), and metabolic characteristics (positron emission tomography, PET).

Conclusion and future prospective

In recent years, cancer research has made significant progress toward more effective, precise, and less intrusive cancer treatments.While nanomedicine in combination with targeted therapy improved the biodistribution of new or already tested chemotherapeutic agents around the specific tissue to be treated, additional techniques, such as gene therapy, siRNA delivery, immunotherapy, and antioxidant compounds, provide cancer patients with new options.Thermal ablation and magnetic hyperthermia, on the other hand, are potential alternatives to tumor resection.Finally, radiomics and pathomics techniques aid in the handling of large data sets generated by cancer patients in order to enhance prognosis and outcomes.

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