According to an increasing body of evidence, original medical research
for vitamin D insufficiency has been linked to an increased vulnerability to
viral and bacterial respiratory infections. Similar findings have recently been
published for COVID-19: researchers discovered a significant association
between vitamin D insufficiency and COVID-19 risk by analyzing publically
available patient data. Furthermore, data suggests that COVID-19 affects black
and minority ethnic people disproportionately, with one possible explanation
being a higher frequency of vitamin D deficiency, among other risk factors. As
a result, it's thought that having enough vitamin D can help minimize the
danger of catching the SARS-CoV-2 virus, as well as the likelihood of severe or
fatal COVID-19 disease.
Mendelian
Randomization (MR) experiments using the genetic
variations associated with serum 25OHD as instrumental variables have been
conducted to investigate the causative role of vitamin D in COVID-19 risk. It
has been demonstrated that a genetic tendency to low vitamin D levels is not
causally linked to infection with SARS-CoV-2 or severe COVID-19 illness.
Methods
Choice of 25OHD genetic instruments
A research manuscript article
used a genome-wide association study (GWAS) to uncover genetic variations that
explain 25OHD levels, which is, to our knowledge, the biggest published GWAS of
25OHD levels. Importantly, this research article took into the season in which vitamin D was
measured to find genetic variations strongly linked to 25OHD levels. SNPs whose
influence on 25OHD level was genome-wide significant (p <
5 10-8), whose minor allele frequency was more than 1%, and with
linkage disequilibrium coefficients (r2) of less than 5% from the
list of conditionally independent variations supplied (using the LDlink tool
and the European 1000 Genomes dataset, excluding Finnish populations).
Discussion
We
examined a link between vitamin D and COVID-19 risk and severity in this
scientific original research paper
by studying a complete set of essential vitamin D variables together for the
first time and employing several techniques to explore the consistency of our
findings. We identified a robust inverse relationship between disease severity
and an integrated ambient UVB measure before disease onset (vitD-UVB). Since
UVB radiation is low at this time of year, particularly in the high northern
latitudes of the UK, the UVB variable's discriminatory power is limited in this
study; nevertheless, more substantial impacts may be detected if UVB variation
is more significant. We only used ambient UVB and did not account for
individual behavioural characteristics that could influence vitamin D
production in the skin, such as the amount of time spent outside, the time of
day spent outside, clothes, etc. It's worth noting that the best predictor of
vitD-UVB is the time of year.
Conclusion
After controlling for confounders,
the researchers observed no significant relationships between COVID-19 risk and
measured 25-OHD levels; however, this finding is constrained by the fact that
vitamin D levels were assessed on average 11 years before the pandemic. Pubrica
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